Cyclopentolate Ophthalmic

What is cyclopentolate ophthalmic?

Cyclopentolate ophthalmic is an eye drop used in veterinary medicine during eye examinations to dilate the pupil and allow for proper examination of the interior part of the eye. It is used in all species of animals.

Cyclopentolate ophthalmic is used off-label in pets as there are no veterinary formulations available. Many drugs are commonly prescribed for off-label use in veterinary medicine. “Off label” means the drug is being used in a way that has not been reviewed or approved by the U.S. Food and Drug Administration (FDA) or Health Canada. In these instances, follow your veterinarian’s directions and cautions carefully, as they may be significantly different from those on the label.

How do I give my pet cyclopentolate ophthalmic?

• Cyclopentolate ophthalmic comes in a liquid drop format to be instilled directly into the eye (topically).
• It is primarily used in a veterinary clinic setting during eye examinations and rarely used at home.
• The recommended dosage is 1 drop to the eye, followed by a second drop 5 minutes later.
• It is recommended to apply the drops 40 to 50 minutes before procedures to allow for maximum dilation of the pupil.
• The lacrimal sac should be compressed by digital pressure for 2–3 min after drop instillation to reduce excessive absorption of this drug into the body.
• Wait for 5 minutes after applying this medicine before applying any other medicines to the eye.

This medication should take effect quickly, within 15 to 60 minutes.

What if I miss giving my pet the medication?

This medication is not prescribed for use at home and will not need multiple scheduled doses.

Are there any potential side effects from cyclopentolate ophthalmic?

Cyclopentolate ophthalmic may cause the following side effects:

• Burning and stinging of the eyes on application
• Increased sensitivity to light
• Blurred vision
• Redness of eyes or increased blood vessel appearance in the eyes

Serious adverse reactions may occur. If any of the following signs develop, stop giving cyclopentolate ophthalmic and contact your veterinarian immediately:

• Punctate keratitis, which appears as small areas of the cornea becoming damaged or inflamed
• Conjunctivitis, sometimes with eyelid involvement (blepharoconjunctivitis)
• Synechiae (adhesions in the eye where the colored iris sticks to the lens or cornea)
• Increased intraocular pressure (IOP)
• Central nervous system and cardiovascular disturbances (when used in smaller animals)

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment. 

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This short-acting medication should stop working within 24–72 hours, although effects can be longer in pets with liver or kidney disease.

Are there any risk factors for this medication?

DO NOT USE cyclopentolate ophthalmic in:

• Pets with certain types of untreated glaucoma or untreated narrow angles in the interior eye
• Pets that are hypersensitive or allergic to this medication

USE WITH CAUTION in:

• Pets that are predisposed to certain forms of glaucoma

Are there any drug interactions I should be aware of?

Several medications should be used with caution when given with cyclopentolate ophthalmic, including:

• Pilocarpine
• Carbachol
• Metoclopramide
• Topiramate

Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this medication?

• Your veterinarian will let you know when they want to reassess your pet to ensure the medication is working and not causing side effects.
• At home, monitor for any side effects such as those noted above. If any side effects occur, discontinue use of the medication and contact your veterinarian.

How do I store cyclopentolate ophthalmic?

• Store cyclopentolate ophthalmic at 46°F–77°F (8°C–25°C).
• Do not freeze.
• Store upright and tightly closed in the original bottle.
• Protect from light and heat.
• Keep medication out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet’s weight and symptoms.