Elias Cancer Immunotherapy (ECI)

What is Elias Cancer Immunotherapy (ECI®)?

Elias Cancer Immunotherapy (ECI®) is a combination autologous vaccine and cell immunotherapy series of injections used to treat osteosarcoma (bone cancer) in dogs. The autologous vaccine and cell therapy use the patient’s own cells for targeted treatment.

It is used off label (extra label) to treat other types of cancer in dogs. Many drugs are commonly prescribed for off-label use in veterinary medicine. “Off label” means the drug is being used in a way that has not been reviewed or approved by the U.S. Food and Drug Administration (FDA) or Health Canada. In these instances, follow your veterinarian’s directions and cautions very carefully, as they may be significantly different from those on the label.

How do I give my pet ECI?

• ECI comes in an injectable form given by your veterinarian.
• Injections are given subcutaneously (under the skin) or intravenously (into the vein).
• Your dog’s tumor will first be surgically removed, then sent to the lab to create the autologous vaccine.
• Once the vaccination series is administered, your veterinarian will collect samples to send to the lab to create the unique T-cell immunotherapy.
• Your veterinarian will then administer the immunotherapy infusions and injections.

This medication should start to work soon after the injections; however, full effects will take several weeks to months to be seen.

What if I miss giving my pet the medication?

This medication is given as a series of injections and infusions by your veterinarian. Follow your veterinarian’s recommendations on what to do if a dose is missed.

Are there any potential side effects from ECI?

ECI may cause the following side effects:

• Redness, mild pain, or swelling at injection site
• Tiredness

Serious adverse reactions may occur. If any of the following signs develop, stop giving ECI and contact your veterinarian immediately:

• An allergic reaction such as irregular breathing, rash, fever, puffiness and swelling around the face
• Changes in heart rate or rhythm

Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses, but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment.

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This long-acting medication will last for several weeks to months.

Are there any risk factors for this medication?

DO NOT USE ECI in:

• Dogs with metastatic disease
• Dogs on immunosuppressive medications
• Dogs that had limb amputation prior to treatment
• Any species other than dogs

USE WITH CAUTION in:

• Dogs with cancers other than osteosarcoma

Are there any drug interactions I should be aware of?

The following medications should be used with caution when given with Elias Cancer Immunotherapy:

• Immunosuppressive drugs (e.g., corticosteroids, chemotherapy agents)
• Immunomodulating drugs or supplements

Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking before starting any new treatment.

Is any monitoring needed with this medication?

• Follow your veterinarian’s directions for lab work monitoring during treatment.
• At home, monitor for any abnormal changes. If any occur, discontinue the medication and contact your veterinarian.

How do I store ECI?

• Your veterinarian will store the medication according to the manufacturer’s directions.
• Keep medication out of reach of children and pets.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility. Be prepared to provide information about the product and your pet's weight and symptoms.